Summary
The effect of chronic converting enzyme inhibition with enalapril on the PRA, PRL
and plasma aldosterone responses to metoclopramide was studied in 10 patients with
mild to moderate essential hypertension. Enalapril reduced supine blood pressure and
increased heart rate significantly. PRA and urinary sodium excretion rose significantly.
PRA levels did not change after metoclopramide neither during placebo nor during enalapril.
The aldosterone response to metoclopramide was not altered by enalapril, indicating
that this response is independent of the renin-angiotensin system. The PRL response
to metoclopramide was considerably enhanced after 4 weeks of treatment with enalapril.
It is proposed that enalapril, by decreasing the formation of angiotensin II, increases
the prolactin reserve.
Key-Words
Enalapril
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Metoclopramide
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Angiotensin II
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Prolactin
